Learning is a life-long process. In fact, it is a process of thinking in which the most significant construct is an individual’s awareness of their own learning and the learning process, in other words, their metacognition. The justification of the present study was to identify the relationship between entrepreneurial dispositions and metacognition and epistemological beliefs that teachers should possess. In line with this, the main aim of the study was to determine the extent to which pre-service teachers’ entrepreneurial dispositions were predicted by metacognition and epistemological beliefs variables. The study was a prediction study and followed a correlational research design. Participants were 516 prospective teachers who studied in a public university in Turkey. Linear regression analyses were conducted using the data collected from Metacognition, Epistemological Beliefs, and Entrepreneurial Dispositions Scales. Analysis results indicated that while planning sub-dimension of the metacognition scale and “Learning depends on ability” and “Learning depends on effort” sub-dimensions of the epistemological beliefs scale positively and significantly predicted entrepreneurial dispositions, organization sub-dimension of the former and “There is only one unchanging truth” sub-dimension of the latter scale were not able to predict entrepreneurial dispositions. The results of the research were discussed in the light of literature and suggestions were presented.